Post by LymeEnigma on Dec 27, 2008 13:45:40 GMT -8
U.S. scientists say they've identified a group of natural killer T cells that play an important role in fighting Lyme disease.
Led by the La Jolla Institute for Allergy & Immunology and Albany Medical College, the researchers said their finding -- based on a mouse model of the disease -- demonstrates white blood cells are central to clearing the bacterial infection and reducing the intensity and duration of arthritis associated with Lyme disease.
In an earlier study published in Nature Immunology, Kronenberg, Sellati and co-workers had shown that a glycolipid, a type of fat, found in the membrane of Borrelia burgdorferi triggered an immune response from the NK T cells. "We had found that if you gave that lipid to mice or humans, it would activate NK T cells," Kronenberg said. While this suggested the cells might play a significant role in Lyme disease, "we were missing in vivo (in the body) evidence showing that the NK T cells were activated following infection and were important for killing and clearing the Lyme disease bacteria," he said, noting that the latest study demonstrates this in an animal model.
Last Edit: Dec 27, 2008 13:53:45 GMT -8 by LymeEnigma