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Post by LymeEnigma on Sept 23, 2008 16:51:01 GMT -8
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Post by LymeEnigma on Sept 23, 2008 16:52:24 GMT -8
Renal involvement in dogs with babesiosis * Authors: Lobetti, R.G. Jacobson, L.S. * ISSN: 00382809 * Volume 72 * Issue 1 * Publication Date:2001 * Pages:p.23-28 * Abstract: Proteinuria, and renal tubular casts and epithelial cells in urine sediment, are commonly observed in both complicated and uncomplicated babesiosis, but do not necessarily reflect or predict renal failure. This study investigated the presence and degree of renal damage in canine babesiosis. Renal function and integrity were evaluated using serum urea and creatinine, serum electrolytes (sodium and potassium), fractional clearance of sodium (FcNa) and potassium (FcK), urine enzyme activity of gamma-glutamyl transpeptidase and alkaline phosphatase, urine protein:creatinine ratio, and urinalysis. One control group (n =10) and 3 groups of babesiosis cases were studied: mild uncomplicated (n =10), severe uncomplicated (n = 11), and complicated (n = 9). All babesiosis groups showed well-concentrated urine. Mean serum urea was elevated in the severe and complicated groups, and was significantly different from the control group. There was no statistically significant difference between the groups for creatinine, although the complicated group had a mean value above the normal reference range. Hypokalaemia was uncommon in all the groups. Hyperkalaemia was present in only 2 dogs in the complicated group. Marginal hyponatraemia was present in a minority of dogs in all groups. The serumelectrolytes were not significantly different between groups. There was no overall elevation, nor any statistically significant difference in both the FcNa and FcK between the groups. Only 1 dog, in the complicated group, showed marked enzymuria. Proteinuria was a common finding and was significantly different between the severe and complicated groups and the control group. Some dogs in all groups had renal tubular epithelial cells in the urinary sediment, which increased in severity from the mild to the complicated groups and was significantly different from the control group. This study demonstrated that minimal renal damage occurs more often in canine babesiosis than significant damage or acute renal failure. www.sabinet.co.za/abstracts/savet/savet_v72_n1_a6.xml
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Post by LymeEnigma on Sept 23, 2008 16:53:55 GMT -8
IMMUNOPATHOLOGY OF THE RENAL COMPLICATIONS OF
BABESIOSISC. R. ANNABLE AND P. A. WARD From the Department of Pathology, The University of Connecticut Health Center, Farmington, Connecticut 06032 Accepted for publication August 15, 1973 Histologic examination of kidneys from rats infected with the hemosporidian protozoan Babesia rodhaini demonstrates the presence of a moderate, acute proliferative glomerulitis. Immunofluorescent studies establish that this renal complication is associated with glomerular deposits of IgG and the third component of complement (C3) in a pattern that is diagnostic for soluble, immune complex-induced nephritis. Acid elution of proteins from involved kidneys leads to the recovery of IgG that is reactive with babesial antigen. In the course of rat babesiosis hypocomplementemia develops, coincident with the parasitemia, severe anemia and glomerular deposits of IgG and C3. Full article (free): www.jimmunol.org/cgi/reprint/112/1/1.pdf*edited to fix formatting.
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