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Post by nyxie63 on Sept 23, 2008 5:58:43 GMT -8
This is sort of related to the western blot cross-reactivity project I've been working on. Interesting stuff with info on various fungal infections in regard to cross-reactivity. cmr.asm.org/cgi/content/full/15/3/465The incidence of invasive fungal infections has increased dramatically in recent decades, especially among immunocompromised patients. However, the diagnosis of these infections in a timely fashion is often very difficult. Conventional microbiologic and histopathologic approaches generally are neither sensitive nor specific, and they often do not detect invasive fungal infection until late in the course of disease. Since early diagnosis may guide appropriate treatment and prevent mortality, there has been considerable interest in developing nonculture approaches to diagnosing fungal infections. These approaches include detection of specific host immune responses to fungal antigens, detection of specific macromolecular antigens using immunologic reagents, amplification and detection of specific fungal nucleic acid sequences, and detection and quantitation of specific fungal metabolite products. This work reviews the current status and recent developments as well as problems in the design of nonculture diagnostic methods for invasive fungal infections.
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Post by LymeEnigma on Sept 23, 2008 6:23:59 GMT -8
Wow! Thanks for posting this!
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Post by nyxie63 on Sept 24, 2008 5:05:23 GMT -8
You're welcome. It's a heckuva article to slog through, but has a great deal of really good info. Btw, any idea of the best way to post that cross-reference list once I get it done? Will probably have to reformat it somehow. It's currently an excel spreadsheet.
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Post by LymeEnigma on Oct 5, 2008 11:21:54 GMT -8
I would start by creating a chart that lists each possibility across the top, and also down one side, and then marking which cross-react with one another, where they intersect.
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