Post by LymeEnigma on Apr 21, 2008 11:08:41 GMT -8
Lyme disease with lymphocytic meningitis, trigeminal palsy and silent thalamic lesionstar, open
Joachim Köchlinga, Corresponding Author Contact Information, E-mail The Corresponding Author, Hans J. Freitagc, Thomas Bollingerb, Alexander Herza and Jürgen Spernera
aKlinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
bInstitut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
cZentrum für Radiologie, Neuroradiologie und Nuklearmedizin, Tesdorpfhaus, Mengstrasse 66-70, D-23552 Lübeck, Germany
Received 23 May 2007;
revised 7 November 2007;
accepted 11 November 2007.
Available online 11 February 2008.
Abstract
We describe a follow-up in a 15-year-old boy with neuroborreliosis diagnosed by clinical symptoms, CSF and serum analysis. MRI revealed a thalamic lesion and an enhancement of the right trigeminal nerve clinically associated with mild hypasthesia in the right maxillary region. Both, clinical symptoms and radiological findings disappeared within 2 months after treatment. Borrelia burgdorferi specific IgM and IgG in CSF and IgG in serum became negative between 6 and 12 months after diagnosis. We show that neuroborreliosis at an early stage may present only with moderate neurological deficits and that at this stage MRI reveals distinct cerebral lesions which might even precede clinical manifestation. Thus, early diagnosis and treatment of neuroborreliosis may prevent persistent neurologic lesions.
Full article: www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WF2-4RTCPWS-1&_user=516213&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000023038&_version=1&_urlVersion=0&_userid=516213&md5=db262591fefc5c4ad64273b3b211ca43
Joachim Köchlinga, Corresponding Author Contact Information, E-mail The Corresponding Author, Hans J. Freitagc, Thomas Bollingerb, Alexander Herza and Jürgen Spernera
aKlinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
bInstitut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
cZentrum für Radiologie, Neuroradiologie und Nuklearmedizin, Tesdorpfhaus, Mengstrasse 66-70, D-23552 Lübeck, Germany
Received 23 May 2007;
revised 7 November 2007;
accepted 11 November 2007.
Available online 11 February 2008.
Abstract
We describe a follow-up in a 15-year-old boy with neuroborreliosis diagnosed by clinical symptoms, CSF and serum analysis. MRI revealed a thalamic lesion and an enhancement of the right trigeminal nerve clinically associated with mild hypasthesia in the right maxillary region. Both, clinical symptoms and radiological findings disappeared within 2 months after treatment. Borrelia burgdorferi specific IgM and IgG in CSF and IgG in serum became negative between 6 and 12 months after diagnosis. We show that neuroborreliosis at an early stage may present only with moderate neurological deficits and that at this stage MRI reveals distinct cerebral lesions which might even precede clinical manifestation. Thus, early diagnosis and treatment of neuroborreliosis may prevent persistent neurologic lesions.
Full article: www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WF2-4RTCPWS-1&_user=516213&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000023038&_version=1&_urlVersion=0&_userid=516213&md5=db262591fefc5c4ad64273b3b211ca43