cave76
Established Member
Posts: 54
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cysts
Oct 13, 2007 14:23:05 GMT -8
Post by cave76 on Oct 13, 2007 14:23:05 GMT -8
APMIS. 2001 May;109(5):383-8. Links
Conversion of Borrelia garinii cystic forms to motile spirochetes in vivo.
Gruntar I, Malovrh T, Murgia R, Cinco M. Institute of Microbiology and Parasitology, Veterinary Faculty, Ljubljana, Slovenia. gruntaig@mail.vf.uni-lj.si
Cystic forms (also called spheroplasts or starvation forms) and their ability to reconvert into normal motile spirochetes have already been demonstrated in the Borrelia burgdorferi sensu lato complex.
The aim of this study was to determine whether motile B. garinii could develop from cystic forms, not only in vitro but also in vivo, in cyst-inoculated mice. The cysts prepared in distilled water were able to reconvert into normal motile spirochetes at any time during in vitro experiments, lasting one month, even after freeze-thawing of the cysts.
Motile spirochetes were successfully isolated from 2 out of 15 mice inoculated intraperitoneally with cystic forms, showing the infectivity of the cysts. The demonstrated capacity of the cysts to reconvert into motile spirochetes in vivo and their surprising resistance to adverse environmental conditions should lead to further studies on the role and function of these forms in Lyme disease.
PMID: 11478686 [PubMed - indexed for MEDLINE]
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cysts
Oct 14, 2007 18:59:43 GMT -8
Post by cobweb2 on Oct 14, 2007 18:59:43 GMT -8
Cavey-may I call you Cavey? Could it be you wanted to put cyst or cysts in the title and not cyts? ;D
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cysts
Oct 15, 2007 9:52:38 GMT -8
Post by LymeEnigma on Oct 15, 2007 9:52:38 GMT -8
What a great find!!! I have a few articles on cystic Lyme (have you read anything done by the Brorson brothers?) but this one really says a lot in just a small amount of space. I'm going to have to add this one to my bookmarks, for sure!
This reminds me of something important I read in another study: that Borrelia may be able to reproduce while in cystic form. That would mean that dormancy is not necessarily safe ... and that a break in remission could potentially be quick, with an immediate boom in bacteria-load.
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cave76
Established Member
Posts: 54
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cysts
Oct 15, 2007 10:07:21 GMT -8
Post by cave76 on Oct 15, 2007 10:07:21 GMT -8
****Cavey-may I call you Cavey? **** The answer's the same. No. And you're right about my misspelled word. Geesh, picky picky picky!!! LOL
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cave76
Established Member
Posts: 54
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cysts
Oct 15, 2007 10:10:15 GMT -8
Post by cave76 on Oct 15, 2007 10:10:15 GMT -8
LE----I'd say that of all the Brorson's articles, this is the one that should be first.
I've always had a bit of 'wariness' about the cysts thang---- but this might be the clincher.
However, always cautious----- it IS done on mice not humans. <g>
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cysts
Oct 15, 2007 15:59:54 GMT -8
Post by LymeEnigma on Oct 15, 2007 15:59:54 GMT -8
Good points. I'm going to try to dig a little deeper on this over the next few days....
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cysts
Oct 18, 2007 16:02:43 GMT -8
Post by cobweb2 on Oct 18, 2007 16:02:43 GMT -8
Bring on the Flagyl !!!!
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cysts
Oct 21, 2007 9:00:28 GMT -8
Post by LymeEnigma on Oct 21, 2007 9:00:28 GMT -8
Is this for real? www.youtube.com/watch?v=Lp01htoTqWUSome good abstracts I found: www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16828236&ordinalpos=3&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14961976&ordinalpos=6&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12051564&ordinalpos=9&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum I have looked and looked ... has anyone been able to find any peer-reviewed material on Flagyl and cysts?
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